The 6th International Conference on Structural Integrity (ICSI2025) will take place in Funchal, Madeira, from September 1 to 4, 2025, at the Pestana Casino Park Hotel & Casino, the location where it began 11 years ago. This venue, with stunning panoramic views of the Atlantic Ocean, is just a short walk from central Funchal. ICSI addresses all aspects and scales of structural integrity, from fundamental principles to emerging trends, with a particular emphasis on multi-scale and multi-physics approaches and applications to new materials and challenging environments. The conference will provide a forum for discussing current research trends in structural integrity, with relevance to aeronautics, space, and other engineering sectors where structural integrity is a key concern.